Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them

Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen

Dérivés substitués du 4-azatricyclo (22.3.1.04.9) octacos-18-ène, leur préparation et les compositions pharmaceutiques les contenant

Abstract

The compounds of formula I wherein either R₁ is hydroxy, R₂ is allyl or n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R₁ is missing, R₂ is allyl and there is a double bond between the carbon atoms numbered 14 and 15, have interesting immunosuppressant and anti-inflammatory properties. They are obtained by fermentation or synthesis, e.g. by hydrogenation or dehydration.

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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    EP-0184162-A2June 11, 1986Fujisawa Pharmaceutical Co., Ltd.Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same

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    EP-0406791-A2January 09, 1991Fujisawa Pharmaceutical Co., Ltd.Composition aqueuse liquide pour utilisation externe
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    EP-0423714-A2April 24, 1991Fujisawa Pharmaceutical Co., Ltd.Hair revitalizing agent
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    EP-0515071-A2November 25, 1992Merck & Co., Inc.O-Aryl, O-Alkyl, O-Alkenyl und O-Alkinylmakrolide mit immunosuppressiver Wirkung
    EP-0838217-A3October 14, 1998SanofiCosmetic composition containing neuropeptide Y receptor antagonist
    EP-2272963-A1January 12, 2011LEK Pharmaceuticals d.d.Procédé de préparation d'un tacrolimus
    GB-2245891-AJanuary 15, 1992Fujisawa Pharmaceutical CoTricyclo compounds
    US-5143918-ASeptember 01, 1992Merck & Co., Inc.Halomacrolides and derivatives having immunosuppressive activity
    US-5147877-ASeptember 15, 1992Merck & Co. Inc.Semi-synthetic immunosuppressive macrolides
    US-5162334-ANovember 10, 1992Merck & Co., Inc.Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
    US-5179087-AJanuary 12, 1993Fisons PlcMacrocyclic compounds
    US-5189042-AFebruary 23, 1993Merck & Co. Inc.Fluoromacrolides having immunosuppressive activity
    US-5208228-AMay 04, 1993Merck & Co., Inc.Aminomacrolides and derivatives having immunosuppressive activity
    US-5208241-AMay 04, 1993Merck & Co., Inc.N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
    US-5215995-AJune 01, 1993Fujisawa Pharmaceutical Co., Ltd.Hair revitalizing agent
    US-5296489-AMarch 22, 1994FisonsImmunosuppressive macrocyclic compounds
    US-5384316-AJanuary 24, 1995Fisons Plc4,16-diazatetracyclo[23.3.1.1.Hu 14,17=b . 0 Hu 4,9 triaconta-16,19-diene-2,3,10-trione derivatives
    US-5514686-AMay 07, 1996Fujisawa Pharmaceutical Co., Ltd.Use of macrolide compounds for eye diseases
    US-5532248-AJuly 02, 1996Merck Co., Inc.O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity
    US-5693648-ADecember 02, 1997Merck & Co., Inc.O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
    US-5770607-AJune 23, 1998Fujisawa Pharmaceutical Co., Ltd.Aqueous liquid composition for external use
    US-6114336-ASeptember 05, 2000SanofiCosmetic composition containing a neuropeptide Y receptor antagonist
    US-6313128-B1November 06, 2001Sanofi-SynthelaboCosmetic composition containing a neuropeptide Y receptor antagonist
    US-6503737-B1January 07, 2003Kosan Biosciences, Inc.Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster
    US-6569867-B2May 27, 2003Kosan Biosciences, Inc.Polyketide derivatives
    US-6624302-B2September 23, 2003Kosan Biosciences, Inc.Polyketide derivatives
    US-6660862-B2December 09, 2003Kosan Biosciences, Inc.Polyketide synthase enzymes and recombinant DNA constructs therefor
    US-6759536-B2July 06, 2004Kosan Biosciences, Inc.Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster
    US-7643885-B2January 05, 2010Siemens AktiengesellschaftIntravenous pacemaker electrode
    US-7714118-B2May 11, 2010Kosan Biosciences IncorporatedPolynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster
    US-8452397-B2May 28, 2013Siemens AktiengesellschaftImplantable pacemaker
    US-RE39762-EAugust 07, 2007Kosan Biosciences, Inc.Polyketide synthase enzymes and recombinant DNA constructs therefor
    WO-0009102-A2February 24, 2000Gpi Nil Holdings, Inc.Carboxylic acids and isosteres of n-heterocyclic compounds for vision and memory disorders
    WO-0009102-A3July 06, 2000Guilford Pharm IncCarboxylic acids and isosteres of n-heterocyclic compounds for vision and memory disorders
    WO-0009109-A2February 24, 2000Gpi Nil Holdings, Inc.Derives de l'acide pipecolique destines aux troubles de la vision et de la memoire
    WO-0009109-A3August 17, 2000Guilford Pharm IncPipecolic acid derivatives for vision and memory disorders
    WO-0009112-A2February 24, 2000Gpi Nil Holdings, Inc.Heterocyclic esters or amides for vision and memory disorders
    WO-0009112-A3June 29, 2000Guilford Pharm IncHeterocyclic esters or amides for vision and memory disorders
    WO-0020601-A2April 13, 2000Kosan Biosciences, Inc.Polyketide synthase enzymes and recombinant dna constructs therefor
    WO-0020601-A3October 26, 2000Kosan Biosciences Inc, Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai WuPolyketide synthase enzymes and recombinant dna constructs therefor
    WO-2007039816-A2April 12, 2007Ranbaxy Laboratories LimitedProcedes de fermentation pour la preparation de tacrolimus
    WO-2007039816-A3July 12, 2007Parveen Kumar, Hitesh Kumar Malviya, Raj Kumar Maurya, Ranbaxy Lab Ltd, Aniruddha ShuklaFermentation processes for the preparation of tacrolimus
    WO-2011004008-A1January 13, 2011Lek Pharmaceuticals D.D.Procédé pour préparation de tacrolimus
    WO-9102736-A1March 07, 1991Fisons Plc, Fujisawa Pharmaceutical Co., Ltd.Macrocyclic compounds
    WO-9104025-A1April 04, 1991Fisons PlcNovel macrocyclic compounds and novel method of treatment
    WO-9113889-A1September 19, 1991Fisons PlcImmunosuppressive macrocyclic compounds
    WO-9203441-A1March 05, 1992Fisons PlcComposes macrocycliques
    WO-9219278-A1November 12, 1992Kurume UniversityUtilisation de composes macrolides pour les maladies des yeux